Morphine
Significant first-pass; often given parenterally for efficacy
Gentamicin
Renally cleared aminoglycoside; little metabolism
Simvastatin
Highly CYP3A4-dependent — interaction-prone
Significant first-pass; often given parenterally for efficacy
Renally cleared aminoglycoside; little metabolism
Highly CYP3A4-dependent — interaction-prone